Open AccessLipid peroxidation system-antioxidant protection and the role of its disorders in the pathogenesis of diabetes mellitus and angiopathies
Author(s) -
А. И. Ляйфер,
M. H. Солун
Publication year - 1993
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11913
Subject(s) - diabetes mellitus , lipid peroxidation , pathological , pathogenesis , population , antioxidant , lipid metabolism , medicine , diabetic angiopathy , physiology , endocrinology , oxidative stress , biology , biochemistry , environmental health
The urgency of the problem of diabetic angiopathies is highlighted by the fact that among patients with insulin-dependent diabetes mellitus under the age of 20 years mortality rate is 7 times higher than the average mortality among the General population, and after reaching 20 years, the average annual risk of mortality is 20 times higher than the total population. Recently, in the study of many pathological conditions, considerable attention has been paid to structurally functional changes in cell membranes. The severity and duration of membrane-damaging processes in the body determine the clinical severity and features of the course of many diseases. Membrane destruction as a pathological phenomenon is primarily due to the involvement of cell membrane lipids in lipid peroxidation processes, which leads to a change in lipid-protein bonds, the strength of the complex of enzymes and other membrane macromolecules, damage to nucleic acids, and impaired cellular metabolism.