Open AccessVasopressin, oxitocin, and corticoliberin-synthesizing hypothalamic structures in rats of both sexes with induced diabetes mellitus
Author(s) -
Yu. М. Kolesnik,
Yu. N. Orestenko,
А. В. Абрамов
Publication year - 1993
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11909
Subject(s) - endocrinology , medicine , vasopressin , hypothalamus , diabetes mellitus , pancreas , glucagon , radioimmunoassay , endocrine system , hormone , biology
The endocrine status of the pancreas and the hypothalamic neurosecretory nuclei were studied by radioimmunoassay, immunocytochemical, morphometric and histochemical methods in Wistar rats of both sexes with experimental diabetes mellitus. The development of diabetes mellitus was characterized by beta-cell destruction and insulin concentrations reduction in these cells and the blood, by increase of glucagon and somatostatin levels in the alfa- and delta-cells, respectively, as well as by the growth of these substances concentrations in the peripheral blood. These changes were parallelled by activation of the vasopressin-, oxitocin and corticoliberin-synthesizing neurones of the paraventricular and supraoptic nuclei of the hypothalamus, as evidenced by morphometric findings and by increase of the blood vasopressin and corticoliberin concentrations and oxitocin level in the hypothalamus. Experimental diabetes mellitus was found to be characterized by activation of the hypothalamo-hypophyseo-adrenal system. Functional differences in the contribution of vasopressin- and oxitocin-synthesizing neurones of the hypothalamic nuclei in the pathogenesis of the disease is shown, as are their sex-specific reactions.