Open AccessActivities of membranebound proteinkinase c and red cell ATPases in diabetic angiopathy
Author(s) -
A.S. Yefimov,
A. A. Serghiyenko,
З. Д. Воробец,
L. M. Serghiyenko
Publication year - 1993
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11896
Subject(s) - diabetes mellitus , angiopathy , medicine , atpase , insulin , endocrinology , diabetic angiopathy , red cell , pathogenesis , cell , chemistry , biochemistry , enzyme
The activities of proteinkinase C, total, Mg2 and Na+, K+-dependent ATPases in red cell membranes were compared in 46 patients with insulin independent, 30 ones with insulin dependent diabetes mellitus with various degrees of vascular disorders, and in 17 patients with atherosclerosis with the predominant involvement of the main vessels of the lower limbs. Diabetes mellitus and the progress of vascular disorders were associated with a more marked depression of proteinkinase C, total and Na+, K+-dependent ATPase activities, this being particularly characteristic of the patients with insulin-independent diabetes and macrovascular disorders, inhibited activities of proteinkinase C and ATPases in red cell membranes in the course of diabetic vascular disorders progress evidence their contribution to the pathogenesis of diabetic angiopathy.