Open AccessHyperlipidemia: a factor contributing to diabetic nephropathy development and progress
Author(s) -
М. В. Шестакова,
И И Дедов,
I. I. Neverov,
E. S. Severghina,
T. G. Dyuzheva,
A. B. Ponomaryov
Publication year - 1993
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11892
Subject(s) - diabetic nephropathy , medicine , dyslipidemia , endocrinology , hyperlipidemia , diabetes mellitus , podocyte , nephropathy , renal biopsy , renal function , kidney , proteinuria
Twenty-nine patients with insulin-dependent diabetes mellitus with similarly manifest renal involvement were examined to elucidate the role of dyslipidemia in diabetic nephropathy progress. Clinicolaboratory parameters (urinary albumin excretion, blood serum levels of total cholesterol, triglycerides, low, very low, and high density lipoprotein cholesterol) and morphologic changes in renal tissue biopsy specimens were analyzed. An increment of the number of large lipid incorporations was observed in various cells of renal glomeruli and interstitium, as well as a high prevalence of low density lipoprotein deposition in glomerular basal membranes and canaliculi as the renal process augmented in severity. Since lipids accumulating in glomerular structures may stimulate mesangial cell proliferation and mesangial matrix hyperproduction, the authors believe that dyslipidemia in diabetes mellitus may be conducive to a more rapid progress of renal disease.