Open AccessThe effect of vitamin E on the development of nephropathy in rabbits with dithizone diabetes
Author(s) -
В. В. Полторак,
Nataliia Gorbenko,
А. И. Гладких,
Ivanova Ov
Publication year - 2000
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11884
Subject(s) - medicine , diabetes mellitus , endocrinology , diabetic nephropathy , microalbuminuria , basal (medicine) , nephropathy , insulin
The effects of vitamin E (VE) on early-stage diabetic nephropathy were studied in experimental insulin-dependent diabetes mellitus. Absolute insulin deficiency was modelled with an intravenous injection of ditisone to male rabbits (35 mg/kg). Vitamin E (tocoferoli acetatas) was given orally as gelatin capsules, 100 mg per animal daily for 2 months. VE-fed rabbits exhibited a significant lowering of basal hyperglycemia, rise of basal insulinemia, and better glucose tolerance than diabetic control. VE also normalized ditisone-increased level of cholesterol, beta-lipoproteins and reduced concentrations of dienic conjugates in blood serum of the diabetic animals. Angioprotective effect of VE manifesting in lowering of microalbuminuria, mass of the kidney and thickness of basal glomerular membrane validates the efficiency of VE in prevention or attenuation of clinical nephropathy in patients with diabetes mellitus.