Open AccessLong-term results of conservative and surgical treatment of patients with diffuse toxic goiter
Author(s) -
N Petrova,
V. N. Khomyakova,
Г. А. Мельниченко
Publication year - 2000
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11878
Subject(s) - medicine , goiter , thyroid , conservative treatment , graves' disease , pediatrics , thyroidectomy , surgery
The disease history, levels of ТЗ, T4, ТТН were investigated and thyroid ultrasonography was made in 111 patients with diffuse toxic goiter (DTG) admitted to hospital in 1984—1993. Of them, '83 had primary DTG, 28 had recurrent thyrotoxicosis. The diagnosis was made in 1978—1993, the treatment was performed in different medical institutions according to the patients ’ residence. The analysis showed that endocrinologists of different clinics practice different policy of thyrostatic treatment (different initial doses of the drugs, different duration of their administration). Out of 98 patients treated with mercasolil recurrence arose in 68%, persistent euthyrosis in 35%, hypothyroidism in 2%>. It is demonstrated that outcome of the conservative treatment does not depend on the initial dose of mercasolil or adjuvant levo-thyroxine but solely on the duration of continuous treatment. After 52 operations recurrences occurred in 35%, hypothyroidism in 36%, euthyrosis in 29%. Recurrent thyrotoxicosis developed as a rule within a year after thyrostatic treatment (84%) and within 5 years after operation (94%).