Open AccessDetermination of autoantibodies to pancreatic antigens in patients with type 1 diabetes mellitus and children from risk groups
Author(s) -
N. L. Vartanyan,
Anna Sominina,
Vladimir V. Zarubaev,
A. S. Stroykova,
I. N. Ostretsova,
О. И. Киселев
Publication year - 2000
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11845
Subject(s) - medicine , autoantibody , diabetes mellitus , type 1 diabetes , antigen , insulin , islet , immunology , endocrinology , antibody
Methodological aspects of immunofluorescent detection of autoantibodies to Langerhans' islet /З-cell antigens (ICA), a marker indicating early preclinical insulin-dependent diabetes mellitus (IDDM), have been modified and standardized. The distribution and levels of ICA were evaluated in patients with first diagnosed IDDM and their relatives (risk group) (total 298). In patients with newly diagnosed IDDM, ICA were detected in 83.3% cases. 15.4% clinically healthy siblings of IDDMpatients and 8.3% children one of whose parents was a diabetic were ICA-positive. About 16% children with non-IDDM carbohydrate metabolism disorders were ICA-positive. Hence, immunofluorescent detection of ICA helps detect this IDDM marker; the process is to be monitored in high-risk children and they should be prescribed therapeutic and prophylactic agents preventing the progress of diabetes.