The cytochrome r-450 system and diabetes | Zendy

И. Е. Ковалев | Zendy; E. I. Rumyantseva | Zendy

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The cytochrome r-450 system and diabetes

Author(s) -

И. Е. Ковалев,

E. I. Rumyantseva

Publication year - 2000

Publication title -

problems of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.124

H-Index - 5

eISSN - 2308-1430

pISSN - 0375-9660

DOI - 10.14341/probl11839

Subject(s) - superfamily , creatures , cytochrome , heme , biochemistry , biology , enzyme , computational biology , chemistry , gene , natural (archaeology) , paleontology

All living creatures from the microbe to humans are endowed with heme-containing enzymes belonging to the superfamily of cytochrome P-450. This superfamily, as has now been established, includes more than 300 isoforms capable of catalyzing at least 60 types of enzymatic reactions with hundreds of thousands of chemical structures [39]. This superfamily of cytochrome P-450 is evolutionarily very ancient and, according to available estimates, exists in wildlife for more than 3.5 billion years [39].

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