Open AccessApoptosis a role in the development of type 1 diabetes
Author(s) -
Т. В. Мохорт,
С. Б. Мельнов,
Vitaly Goranov
Publication year - 2000
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11838
Subject(s) - apoptosis , programmed cell death , organism , diabetes mellitus , cytotoxic t cell , pathological , microbiology and biotechnology , biology , mechanism (biology) , immunology , affect (linguistics) , insulin , medicine , endocrinology , psychology , in vitro , communication , genetics , philosophy , epistemology
In recent decades, the attention of biologists and doctors of various specialties has been attracted by the phenomenon of apoptosis a genetically programmed process of death and utilization of committed cells with the participation of biochemical reactions controlled by the whole organism [6 |. This process starts as a result of the interaction of the regulatory systems of the body and (or) direct contact with biologically active substances that directly or indirectly affect the functional state of the cells [2]. Obviously, apoptosis is of great importance for the processes that ensure the physiological renewal of tissues in the body, and for pathological processes, in particular autoimmune, accompanied by cell death. At present, there is sufficient reason to assert that insulin-dependent diabetes mellitus (IDDM) occurs as a result of the death of P-cells (CD) as a result of the cytotoxic effect of immunological agents and (or) certain chemicals [1] that proceeds with the participation of apoptosis.