Open AccessImpact of rotational stress on immunity parameters. Role of opiate receptors
Author(s) -
С. В. Гейн,
T. A. Simonenko,
S. P. Tendryakova
Publication year - 2003
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11793
Subject(s) - blockade , immune system , receptor , antibody , opiate , spleen , immunology , stimulation , (+) naloxone , immunity , titer , medicine , endocrinology , antagonist
Experiments on non-inbred male mice used a model of rotational stress to examine the impact of 8-, p- к-opiate receptor blockade on antibody formation, delayed-type hypersensitivity (DTH), changes in the count of antibody-forming cells (AFC) and nucleated cells of lymph nodes and spleen during a local immune response. Rotational stress was found to cause a slightly pronounced inhibition of immune inflammation in DTH, a considerable increase in the count of AFC and nucleated cells in the regional lymph nodes, without changing the titers of antibodies from peripheral blood. Naloxone blockade of 8-, p- к-opiate receptors abolished these effects of stress. It has been suggested that abolishment of the promoting effect of rotational stress on the count of AFC and on the depression of DTH may be associated with the blockade of effects of ^-endorphin and met-enkephalin that act predominantly via stimulation of 8-receptors.