Open AccessDecreased glucorticoid sensitivity as a factor of stressogenic shifts in the activity of monoamine oxidase, lipid peroxidation, and behavior in rats
Author(s) -
I. A. Volchegorsky,
Vadim Tseĭlikman,
Denis S. Smirnov,
Степан Александрович Шип,
A. V. Borisenkov
Publication year - 2003
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11779
Subject(s) - lipid peroxidation , monoamine oxidase , endocrinology , medicine , chemistry , hormone , glucocorticoid , anxiogenic , enzyme , oxidative stress , biochemistry , receptor , anxiolytic
Four episodes of immobilization stress cause a decrease in the sensitivity to glucocorticoid hormones, followed by anxiogenic behavioral disorders, enhanced monoamine oxidase-В (МАО-В) activity and simultaneously increased lipid peroxidation (LPO) in the brain tissue of rats. Concurrently, there is an increase in renal МАО-В activity, as well as renal and hepatic accumulation of LPO products. Administration of kenalog (2 mg/kg), a pharmacological analogue of glucocorticoid hormones, prevents the poststress МАО-В activation and LPO and attenuates anxiogenic behavioral disorders in the rats.