Decreased glucorticoid sensitivity as a factor of stressogenic shifts in the activity of monoamine oxidase, lipid peroxidation, and behavior in rats | Zendy

I. A. Volchegorsky | Zendy; В. Э. Цейликман | Zendy; Denis S. Smirnov | Zendy; Степан Александрович Шип | Zendy; A. V. Borisenkov | Zendy

Open Access

Decreased glucorticoid sensitivity as a factor of stressogenic shifts in the activity of monoamine oxidase, lipid peroxidation, and behavior in rats

Author(s) -

I. A. Volchegorsky,

В. Э. Цейликман,

Denis S. Smirnov,

Степан Александрович Шип,

A. V. Borisenkov

Publication year - 2003

Publication title -

problems of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.124

H-Index - 5

eISSN - 2308-1430

pISSN - 0375-9660

DOI - 10.14341/probl11779

Subject(s) - lipid peroxidation , monoamine oxidase , endocrinology , medicine , chemistry , hormone , glucocorticoid , anxiogenic , enzyme , oxidative stress , biochemistry , receptor , anxiolytic

Four episodes of immobilization stress cause a decrease in the sensitivity to glucocorticoid hormones, followed by anxiogenic behavioral disorders, enhanced monoamine oxidase-В (МАО-В) activity and simultaneously increased lipid peroxidation (LPO) in the brain tissue of rats. Concurrently, there is an increase in renal МАО-В activity, as well as renal and hepatic accumulation of LPO products. Administration of kenalog (2 mg/kg), a pharmacological analogue of glucocorticoid hormones, prevents the poststress МАО-В activation and LPO and attenuates anxiogenic behavioral disorders in the rats.

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