Open AccessNeuroendocrine mechanisms responsible for experimental anovulation of hyperandrogenie origin
Author(s) -
Alexander Reznikov,
P. V. Sinitsyn,
Л. В. Тарасенко,
L. I. Polyakova
Publication year - 2002
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11732
Subject(s) - anovulation , endocrinology , medicine , ovulation , estrous cycle , hormone , flutamide , testosterone (patch) , biology , polycystic ovary , diabetes mellitus , insulin resistance , androgen receptor , prostate cancer , cancer
An experimental model of anovulatory infertility of hyperandrogenic origin (subcutaneous implantation of silastic capsules with testosterone to mature female rats) was used to study morphological, hormonal, and biochemical indices that characterize the hypothalamic-pituitary-ovarian system. Disorders found in the functional metabolism of androgens in the hypothalamus, decreased pituitary response to hypothalamic hormone (HH), changes in the pattern of estrous cycles, ovarian morphological changes suggest that there are neuroendocrine disturbances ovulation regulation. The use of flutamide as a drug of experimental antiandrogenic therapy led to a partial normalization of hormonal, biochemical, and morphological characteristics and to recovery of fertility in female rats with anovulatory fertility.