Open AccessThe effects of coordination zinc compound on glucose uptake and the activity of tissue pyruvate dehydrogenase in rats with experimental diabetes mellitus
Author(s) -
A. A. Samigzhonov,
M. Zh. Ergasheva,
Tаlаt Sааtоv
Publication year - 2002
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11730
Subject(s) - medicine , diabetes mellitus , endocrinology , pyruvate dehydrogenase complex , alloxan , chemistry , diaphragm (acoustics) , zinc , lactate dehydrogenase , carbohydrate metabolism , dehydrogenase , skeletal muscle , biochemistry , enzyme , organic chemistry , physics , acoustics , loudspeaker
Zinc compounds were examined for their effects on the transport of glucose through the membrane and on the activity of pyruvate dehydrogenase of mitochondria of the hearts and skeletal muscles from rats with experimental diabetes mellitus. The objects of the investigations were the rat diaphragm, cardiac and skeletal muscle mitochondria.
The aim of the investigation was to study the effect of the coordination zinc compound piracine on the transport of glucose in the diaphragm and on the activity of pyruvate dehydrogenase of the hearts and skeletal muscles from rats with experimental diabetes mellitus.
Experimental diabetes mellitus was induced by intraperitoneal alloxan hydrate during fasting.
The investigation established that piracine exerted a stimulating effect on glucose transport in experimental diabetes. With the coordination zinc compound, there was an increase in the activity of pyruvate dehydrogenase, which is lowered in diabetes.
The findings provide again evidence for the role of zinc ions in glucose transport and oxidation.