Impact of anxiogenic stress on glucocorticoid sensitivity, glucose tolerance, and alloxan resistance in rats | Zendy

I. A. Volchegorsky | Zendy; В. Э. Цейликман | Zendy; Степан Александрович Шип | Zendy; N. V. Bubnov | Zendy; A. I. Sinitsky | Zendy

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Impact of anxiogenic stress on glucocorticoid sensitivity, glucose tolerance, and alloxan resistance in rats

Author(s) -

I. A. Volchegorsky,

В. Э. Цейликман,

Степан Александрович Шип,

N. V. Bubnov,

A. I. Sinitsky

Publication year - 2002

Publication title -

problems of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.124

H-Index - 5

eISSN - 2308-1430

pISSN - 0375-9660

DOI - 10.14341/probl11724

Subject(s) - anxiogenic , alloxan , endocrinology , medicine , glucocorticoid , open field , corticosterone , diabetes mellitus , chemistry , hormone , anxiolytic , receptor

Four episodes of immobilization stress caused anxiogenic behavioral disorders accompanied by a decrease in sensitivity to glucocorticoid hormones, by an increase in the activity of monoaminooxidase (MAO-B) in the brain tissue, an enhancement in glucose load tolerance, and a reduction in acute hypoxia tolerance in rats. Alloxan-induced diabetes was also associated with a reduction of rat behavioral activity in the open field along with an increase in the cerebral activity of MAO-B. Prior anxiogenic stress potentiated an alloxan-induced increase in cerebral MAO- B activity, enhanced concomitant behavioral disorders in rats, and increased the hyperglycemic effect of alloxan.

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