Open AccessImpact of anxiogenic stress on glucocorticoid sensitivity, glucose tolerance, and alloxan resistance in rats
Author(s) -
I. A. Volchegorsky,
Vadim Tseĭlikman,
Степан Александрович Шип,
N V Bubnov,
А. И. Синицкий
Publication year - 2002
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11724
Subject(s) - anxiogenic , alloxan , endocrinology , medicine , glucocorticoid , open field , corticosterone , diabetes mellitus , chemistry , hormone , anxiolytic , receptor
Four episodes of immobilization stress caused anxiogenic behavioral disorders accompanied by a decrease in sensitivity to glucocorticoid hormones, by an increase in the activity of monoaminooxidase (MAO-B) in the brain tissue, an enhancement in glucose load tolerance, and a reduction in acute hypoxia tolerance in rats. Alloxan-induced diabetes was also associated with a reduction of rat behavioral activity in the open field along with an increase in the cerebral activity of MAO-B. Prior anxiogenic stress potentiated an alloxan-induced increase in cerebral MAO- B activity, enhanced concomitant behavioral disorders in rats, and increased the hyperglycemic effect of alloxan.