Open AccessA rare case of pseudohypoparathyroidism
Author(s) -
V. A. Gubkina,
Т. С. Камынина,
Е. В. Корнилова,
А. В. Древаль
Publication year - 2019
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11704
Subject(s) - pseudohypoparathyroidism , adenylate kinase , endocrinology , parathyroid hormone , osteodystrophy , medicine , pathological , cyclase , receptor , hormone , biology , calcium
Pseudohypoparathyroidism (PGPT) - Albright's hereditary osteodystrophy is a sex-related disease rarely seen in medical practice. Inherited by the dominant type. It is caused by insensitivity of the kidneys and bones to parathyroid hormone (PG), which is secreted in normal or slightly elevated amounts [6, 10]. GH may not have a specific effect on cells due to pathology of GH receptors, impaired expression of information RNA synthesis by an unchanged hormone-receptor complex, the presence of pathological components of adenylate cyclase, pathological AMP-dependent protein kinase, or a defect in the synthesis of kinase substrates in the presence of circulating GH antagonists [5, 10 ].