Open AccessHypoglycemic effect of stress exposures and their use for experimental prevention of diabetes mellitus
Author(s) -
I. A. Volchegorsky,
Vadim Tseĭlikman,
О. Л. Колесников,
Yu. K. Kostin,
A. A. Kolesnikova,
Natalia Skobeleva,
I. A. Vyazovsky,
R. I. Lifshits
Publication year - 1995
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11494
Subject(s) - hypoglycemia , diabetes mellitus , medicine , alloxan , endocrinology , stressor , stomach , stress hyperglycemia , insulin , glucagon , clinical psychology
The effects of acute and chronic immobilization stress and of a biogenic stressor, prooxidant (neutrophilokin) on the level of glycemia and resistance to diabetogenic exposures were studied in rats. A relationship between the poststress changes in glycemia and the regime of food intake has been revealed: acute stress on an empty stomach led to hypoglycemia, whereas stress without alimentary deprivation caused hyperglycemia. Prestress of fed animals abolished the hypoglycemic effect of stress on an empty stomach and transformed it into a hyperglycemic reaction which could be prevented by obsidan. Stress-induced hypoglycemia was realized against the background of reduced sensitivity to glucocorticoids and increased insulin sensitivity, with the concentration of the circulating hormone unchanged. The detected regularities are regarded as the mechanism of diabetes preventing action of chronic stress upon alloxan challenge. Repeated immobilization stresses in parallel with obsidan injections are characterized by the highest preventive effect.