Open AccessSegregation analysis of diffuse toxic goiter
Author(s) -
А. Р. Kalinin,
О. Р. Sidorova,
Tamara Kamynina
Publication year - 1995
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11484
Subject(s) - proband , inheritance (genetic algorithm) , disease , medicine , genetics , pathology , biology , mutation , gene
The authors discuss segregation analysis of diffuse toxic goiter based on 34 histories selected for the proband. In 11 families one of the parents and the child were ill, in 23 the proband’s parents were healthy. Weinberg’s method of solitary registration was used. No correspondence of the monogenic model of disease inheritance was observed for families with the hypothesized autosomal dominant and autosomal recessive types of inheriting.