Open AccessContribution of various sections of the hypothalamus to the pathogenesis of experimental diabetes mellitus in rats
Author(s) -
Yu. М. Kolesnik,
А. В. Абрамов,
Гліб Володимирович Василенко,
V. A. Zhulinsky
Publication year - 1995
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11480
Subject(s) - pathogenesis , diabetes mellitus , endocrinology , hypothalamus , medicine , stimulation , hormone , endocrine system
The status of subnuclei of the paraventricular and ventromedial nuclei of the hypothalamus in the pathogenesis of experimental diabetes mellitus was studied in Wistar rats by morphohistochemical, radioimmunological, immunocytochemical, and electrophysiological methods. A close correlation was revealed between morphohistochemical and hormonal characteristics of the neuronal status of the studied hypothalamic subnuclei, on the one hand, and of their bioelectrical activity, on the other. The reactions of the subnuclei of paraventricular and ventromedial nuclei during development of diabetes were found to differ. The hypofunction of the ventrolateral subnucleus of the ventromedial nucleus was shown to be one of the mechanisms of compensation of diabetes mellitus, directed, together with other mechanisms, at stimulation of insulin biosynthesis. The results confirm the important role of the hypothalamic structures in the regulation of the endocrine function of the pancreas and in the pathogenesis of diabetes mellitus.