Open AccessFunctional activity of ATP-dependent K+ channels of pancreatic beta-cells in experimental diabetes mellitus and their reaction to sulfonylurea agents
Author(s) -
В. Н. Бабичев,
N. S. Ignatyev,
М. И. Балаболкин
Publication year - 1995
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11477
Subject(s) - sulfonylurea , medicine , exocytosis , endocrinology , insulin , glibenclamide , sulfonylurea receptor , diabetes mellitus , chemistry , secretion , pharmacology
Analysis of the status of ATP-dependent K+ channels of pancreatic beta cells functionally attenuated under the effect of streptozotocin and simultaneous assessment of their reaction to sulfonylamide agents glybenclamide, glipizid, and glyclazid showed highly specific response of the tested ionic channels under the effect of both glucose and sulfonylurea agents. Analysis of the time course of electrophysiological processes coursing in them showed appreciable changes in the time of the channel closing, which led to deceleration of insulin secretion starting from the moment of exposure to glucose or sulfonylurea agents till exocytosis of insulin quantum. Glybenclamide proved to be the most active of the tested agents as regards their secretogenic properties.