Open AccessParathyroidin effect on cerebrovascular resistance
Author(s) -
Yu. Ya. Chursina,
D. N. Khudaverdyan
Publication year - 1995
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11463
Subject(s) - cats , perfusion , blood pressure , vascular resistance , medicine , hemodynamics , cardiology , cerebral perfusion pressure , anesthesia
Effects of parathyroidin in various doses on cerebrovascular resistance was studied in narcotized cats by resistography. Changes in systemic arterial pressure were recorded in parallel with this. A hypotensive dose-dependent effect of the drug was revealed, which manifested at the first minute by reduction of both arterial and perfusion pressure. The reduction of perfusion pressure reflecting a drop of cerebrovascular resistance was less pronounced than arterial pressure decrease. The said parathyroidin effect did not depend on its hypercalcemic effect which manifested much later. A suppressive action of exogenous parathyroid hormone on the transmembranous release of calcium ions in the smooth-muscle cells of the vessels is believed to underlie the detected hemodynamic shifts. These data may be useful in designing schemes of therapeutic correction of cerebral circulation disorders