Open AccessPathophysiology of the microcirculatory bed in obesity
Author(s) -
В. A. Zelinsky,
Serhii A. Sokur
Publication year - 1995
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11458
Subject(s) - microcirculation , vascular permeability , capillary action , hematocrit , oxygen , oxygen tension , medicine , cardiology , permeability (electromagnetism) , chemistry , materials science , biochemistry , organic chemistry , membrane , composite material
A total of 207 patients with alimentary constitutional and hypothalamic obesity were examined in order to assess the status of the microcirculatory bed, including the status of capillary walls, hemocirculation, transcapillary metabolism, oxygen delivery to tissues in patients with various forms of obesity. Bulbobiomicroscopy, assessment of capillary wall permeability by the hydrostatic test, polarographic study of oxygen tension in the skin using oxygen and ischemic test were employed. Obese patients were found to develop appreciable microcirculatory disorders (vascular, intravascular, extravascular); capillary walls became better penetrable for liquid and proteins and the adaptation reserve of these vessels decreased, with the substrate movement from blood to tissues predominating. A correlation has been traced between the status of the circulation and capillary walls, and extravascular shifts, on the one hand, and capillary permeability, on the other. Oxygen delivery to tissues was disordered in obese patients, this manifesting by deterioration of both oxygen delivery and consumption. The degree of impairment of various components of microcirculation and oxygen supply of tissues augmented with body mass increase.