Open AccessEndocrine and messenger systems during adaptation to high-altitude conditions
Author(s) -
A. A. Vishnevsky,
D. Z. Zakirov,
V. M. Yakovlev,
L. Y. Zholdubayeva,
Г. А. Захаров
Publication year - 2003
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11447
Subject(s) - second messenger system , hormone , endocrine system , epinephrine , messenger rna , adaptation (eye) , medicine , endocrinology , biology , chemistry , signal transduction , neuroscience , microbiology and biotechnology , biochemistry , gene
Of endocrine cascades and messenger systems, the authors conducted this study involving two series of experiments. The pattern of interaction of hormones and secondary messengers while adapting to high-altitude was clarified in the first series. The response of phosphoinositide to exogenous epinephrine was examined in the second series. The experimental data are represented as primary mean values ± standard deviations. Two phases of activity of the hormonal system are shown. These are the excitation of the hypothalamopituitary cascade and the enhanced production of glucocorticoids and catecholamines during early adaptation and the return of activity of the hormonal system to the baseline values by day 14 of adaptation. By that time the rearrangements in the phosphoinositide messenger system consists in increasing the proportion of polyphosphoinositides in the total membranous fraction of inositol-containing phospholipids, in adrenalectomized animals to a greater extent. The above events give rise to new coordination relations between hormones and secondary messengers. It is concluded that that the phosphoinositide messenger system is involved in the formation of defense mechanisms the reduce the destructive effects of large amounts of epinephrine.