Open AccessNeurophysiological effects of corticotropin-releasing factor in the undergoing sections of the olfactory area of the rat cerebral cortex
Author(s) -
А. А. Мокрушин,
V. G. Shalyapina
Publication year - 2003
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11446
Subject(s) - excitatory postsynaptic potential , postsynaptic potential , long term potentiation , inhibitory postsynaptic potential , glutamatergic , chemistry , neuroscience , cerebral cortex , piriform cortex , olfactory system , medicine , endocrinology , biophysics , central nervous system , biology , glutamate receptor , biochemistry , receptor
Application of corticotrophin-releasing factor (CPF) in concentrations of 10-9-10-8 M on the rat olfactory cortex slices induced activation of the pre- and postsynaptic excitatory components of the focal potentials recorded in the slices. The amplitude and duration of α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic and N-methyl-D-aspartate components of postsynaptic evoking potentials increased upon exposure to CRF, while the amplitude of GABAB-mediated inhibitory postsynaptic potentials was suppressed. At higher concentrations of CRF (10-8 M) epileptiform charges were recorded in the cells. CRF effects were reversible and eliminated after washing. A long (90 min) exposure induced the phenomena similar to long-term posttetanic potentiation. The findings suggest that CRF has pronounced activating properties and ajfects the glutamatergic and GABAergic systems.