Open AccessThe value of the simultaneous determination of content
glycated proteins and antibodies to islet cells
in children and adolescents
Author(s) -
Мохира Акмаловна Айходжаева,
Gulnara Rakhimova,
Z. S. Akbarov,
M. V. Zalyalieva,
Ш У Ахмедова
Publication year - 2004
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11401
Subject(s) - glycated hemoglobin , islet , medicine , endocrinology , antibody , diabetes mellitus , glycemic , antigen , insulin , immunology , type 2 diabetes
An assessment was made of the potentiality of identification of individuals at risk for type 1 diabetes mellitus (DM) among children with transient hyperglycemia by simultaneously determining the levels of antibodies to pancreatic islet cell antigens (ICA) and insulin antigen (IA), as well as glycated proteins of different life span.
The content of antibodies to ICA and IA was measured in 76 children and adolescents aged 3 to 20 years who had a history of transient hyperglycemia and in 18 children of the same age who had DM-characteristic complaints. They also underwent a glucose tolerance test and the levels of glycated hemoglobin (HbAlc), glycated hair keratin (GHK), and glycated fibrinogen (GF) were determined.
The children with a history of transient hyperglycemia, those with impaired glucose tolerance, and a group of individuals with fasting glycemic disturbances were found to have higher levels of glycated proteins (GHK and HbAlc) and a significantly more frequency of and higher titers of antibodies to IS and ICA than in the children from the control group and in those without carbohydrate metabolic disturbances.