Open AccessComponents of the hamkergic system and its function in the endocrine glands
Author(s) -
T. M. Mishunina
Publication year - 2004
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11388
Subject(s) - receptor , endocrine system , central nervous system , mediator , inhibitory postsynaptic potential , intracellular , nervous system , biology , neuroscience , function (biology) , amino acid , microbiology and biotechnology , mechanism of action , chemistry , endocrinology , biochemistry , hormone , in vitro
In the first years after the discovery in the brain of vertebrates of gamma-aminobutyric acid (GABA), which was later recognized as the main inhibitory mediator of the central nervous system, it was believed that it was localized exclusively in the cells of the nervous system. An increase in the sensitivity of GABA determination methods allowed later to establish the presence of amino acids, enzymes of its metabolism, transport systems, as well as receptors in cells of other tissues and organs. The mechanism of action of GABA on the periphery is mediated by both membrane receptors (in the case of transmission of a nerve impulse or trophic effect), and without their participation (in the regulation of intracellular processes)