Open AccessThe hormonal function of human gonads and adrenals at various age
Author(s) -
Н. П. Гончаров,
G. V. Katsiya
Publication year - 1995
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11366
Subject(s) - hormone , endocrinology , medicine , testosterone (patch) , androgen , dehydroepiandrosterone , radioimmunoassay , age groups , period (music) , hydrocortisone , physiology , demography , physics , sociology , acoustics
Results of radioimmunoassay of the adrenal and sex hormones and their precursors in the peripheral blood of men of different age groups are presented. The measurements were carried out in men of mature age of the two periods (22 to 35 years of age. I period, and 36 to 60. II period), elderly subjects aged 61 to 74, senile ones aged 75 to 90, and in long-livers aged 91 to 112. The content of the principal adaptive hormone, hydrocortisone, and its immediate precursor 11-deoxyhydrocortisone was found to be virtually the same in all age groups. At the same time, the levels of other precursors – pregnanediole, 17-hydroxypregnanediole and 17-hydroxyprogesterone progressively reduce with age. An inverse correlation can be traced between the level of the principal adrenal androgen, dehydroepiandrosterone, and the age of the examined men. In contrast to testosterone, the content of 5alfa-dehydrotestosterone is reliably reduced in elderly age and remains at this level in the subsequent years.