Open AccessEffect of repeated stress exposures on body sensitivity to glucocorticoids and insulin
Author(s) -
V. Ye. Tseilikman,
I. A. Volchegorsky,
О. Л. Колесников,
I. A. Vyazovsky,
I. A. Ghiyenko,
A. A. Kolesnikova,
O. A. Afanasyev,
R. I. Lifshits
Publication year - 1995
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11349
Subject(s) - insulin , glucocorticoid , endocrinology , medicine , insulin sensitivity , coma (optics) , hydrocortisone , insulin resistance , physics , optics
Effects of repeated stress exposures on the sensitivity to exogenous glucocorticoids and insulin were studied. The reaction to glucocorticoids was assessed by the sensitivity of lymphoid organs and peripheral blood in response to administration of a synthetic long-acting glucocorticoid analog kenalog. Insulin sensitivity was assessed from the latency of development of insulin coma. Repeated stress exposures were found to appreciably limit the changes in the thymus and spleen caused by exogenous glucocorticoids. This permitted a conclusion about the capacity of repeated stress exposures to reduce the sensitivity of an organism to the effects of exogenous glucocorticoids. Moreover, these exposures reduced the latency of insulin coma development, this indicating an increased insulin sensitivity of the body. Combination of repeated stress exposures with drug blocking of adrenoreceptors with obsidan in a dose of 0.05 mg per animal increased the latency of insulin coma development.