Open AccessUse of dexamethasone for the differential diagnosis of dwarfism
Author(s) -
С. С. Панкова,
Т I. Buraya,
N. Р. Goncharov
Publication year - 1995
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11330
Subject(s) - dexamethasone , endocrinology , dwarfism , medicine , somatotropic cell , basal (medicine) , pituitary gland , hormone , biology , insulin , biochemistry , gene
The capacity of somatotrophs to respond with secretion of growth hormones to dexamethasone administration was studied in children with different forms of dwarfism. In cases of growth delay caused by deficiency of growth hormone the content of STH during dexamethasone test was at the basal level. In the rest cases blood plasma (serum) STH levels increased at the 180th min after dexamethasone administration. A 6 to 50-fold increase of blood STH level was observed in the presence of intact somatotropic function of the hypophysis. Dexamethasone is recommended for the assessment, of the function of somatotrophic state in practical medicine.