Open AccessThe effect of chronic stress on collagen metabolism in rat bone tissue with alloxan diabetes
Author(s) -
N.V. Savinova,
Е. Г. Бутолин
Publication year - 2004
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11307
Subject(s) - hydroxyproline , alloxan , endocrinology , medicine , diabetes mellitus , insulin , chemistry , metabolism
The study was undertaken to examine the time course of changes in the parameters of collagen metabolism in the bone of rats with alloxan diabetes under chronic stress. The levels of free hydroxyproline, total collagen and its fractions were comparatively studied in the bone of rats with alloxan diabetes alone and in combination with immobilization stress. The concentrations of C-peptide and insulin were measured in the serum of experimental animals. In the studied tissues of rats with alloxan diabetes exposed to stress, the content of a neutrally salt-soluble fraction of collagen was less and that of the citrate-soluble fraction was higher than that in rats with isolated diabetes. The concentration of a neutrally salt-soluble fraction of collagen in the studied tissues correlated with the blood level of insulin in both experimental groups of animals throughout the experiment. The content of total collagen in the bone of rats with alloxan diabetes and an additional stress load was less than that in rats with isolated diabetes.