Open AccessCorticotropinomas. Early diagnosis and therapy (Lecture)
Author(s) -
V Ye Semin,
Yu K Trunin
Publication year - 1994
Publication title -
problemy èndokrinologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.124
H-Index - 5
eISSN - 2308-1430
pISSN - 0375-9660
DOI - 10.14341/probl11294
Subject(s) - basophilic , autopsy , eosinophilic , incidence (geometry) , pathology , medicine , optics , physics
A systematic study of patients who died from various diseases shows the presence of pituitary tumors in 6.8-22.6% of cases. In fact, in many cases, neither doctors nor patients are even aware of their existence. This was first noticed by Costello in 1929. Using standard methods for staining autopsy material, he divided most tumors into 4 groups: chromophobic (52.8%), resembling eosinophilic (7.5%), basophilic (27.2% ), mixed (12.4%).
These were the first steps in the study of pituitary adenomas. With the advent of adequate histochemical techniques, chromophobic adenomas began to be regarded as secretory-active. However, the high incidence of autopsy adenomas contrasts sharply with the relatively low incidence of clinically apparent tumors.