THE RELEVANCE, BENEFITS AND CLINICAL PERSPECTIVES OF THE COMBINED TREATMENT OF OSTEOPOROSIS BASED ON BONE-ANABOLIC THERAPY | Zendy

Larisa Marchenkova | Zendy; E. Yu Martynova | Zendy

Open Access

THE RELEVANCE, BENEFITS AND CLINICAL PERSPECTIVES OF THE COMBINED TREATMENT OF OSTEOPOROSIS BASED ON BONE-ANABOLIC THERAPY

Author(s) -

Larisa Marchenkova,

E. Yu Martynova

Publication year - 2015

Publication title -

osteoporosis and bone diseases

Language(s) - English

Resource type - Journals

eISSN - 2311-0716

pISSN - 2072-2680

DOI - 10.14341/osteo2015220-24

Subject(s) - teriparatide , raloxifene , denosumab , osteoporosis , medicine , combination therapy , anabolic agents , pharmacotherapy , oncology , breast cancer , tamoxifen , bone mineral , cancer

Combination therapy of osteoporosis based on bone-anabolic and antiresorbtive agents has a great clinical perspective. An analysis of available publications shows that combination therapy is appropriate from the standpoint of increasing the effectiveness of treatment. Combination therapy can be executed as a simultaneous use of teriparatide with denosumab, raloxifene or hormonal therapy, and the subsequent administration of bisphosphonates, denosumab or raloxifene after treatment with teriparatide. The review presents the evidence-based data on the effect of combined and sequential regimens for osteoporosis fracture risk.

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