Open AccessOSTEOPOROSIS: CELLULAR AND MOLECULAR MECHANISMS OF DEVELOPMENT AND TARGET MOLECULES IN SEARCH FOR NEW TREATMENTS OF THE DISEASE
Author(s) -
С. Сагаловски
Publication year - 2012
Publication title -
osteoporoz i osteopatii
Language(s) - English
Resource type - Journals
eISSN - 2311-0716
pISSN - 2072-2680
DOI - 10.14341/osteo2012115-22
Subject(s) - wnt signaling pathway , osteoporosis , rankl , mechanism (biology) , signal transduction , cell signaling , disease , bioinformatics , medicine , computational biology , microbiology and biotechnology , biology , receptor , philosophy , epistemology , activator (genetics)
In a review of the literature reflects the modern understanding of the cellular-molecular mechanism development of osteoporosis. Reflects the importance of cytokine RANKL-RANK-OPG sistem and Wnt/β-catenin signaling pathway in the development process of osteoblasto- and osteoclastogenesis. Noting the key role in the process of bone formation a number of molecules of cell signaling pathway and their antagonists are of interest as a target molecule to search for new drugs treatment for osteoporosis.