ROL' KAL'TsIY-ChUVSTVITEL'NOGO RETsEPTORA V PODDERZhANII SISTEMY KAL'TsIEVOGO GOMEOSTAZA | Zendy

Svetlana Mirnaya | Zendy; Ekaterina Pigarova | Zendy; Anna V. Belyaeva | Zendy; Н. Г. Мокрышева | Zendy; A. N. Tyulpakov | Zendy; Liudmila Rozhinskaya | Zendy

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ROL' KAL'TsIY-ChUVSTVITEL'NOGO RETsEPTORA V PODDERZhANII SISTEMY KAL'TsIEVOGO GOMEOSTAZA

Author(s) -

Svetlana Mirnaya,

Ekaterina Pigarova,

Anna V. Belyaeva,

Н. Г. Мокрышева,

A. N. Tyulpakov,

Liudmila Rozhinskaya

Publication year - 2010

Publication title -

osteoporosis and bone diseases

Language(s) - English

Resource type - Journals

eISSN - 2311-0716

pISSN - 2072-2680

DOI - 10.14341/osteo2010332-36

Subject(s) - calcium sensing receptor , calcium , calcium metabolism , receptor , homeostasis , apoptosis , gene , chemistry , function (biology) , endocrinology , medicine , microbiology and biotechnology , biology , biochemistry

Calcium-sensing receptor (CaSR), a member of G proteincoupledreceptors family, plays a key role in systemic calciumhomeostasis regulation. It is expressed in a variety of tissues, andis responsible for maintaining plasma calcium concentration.In addition, the CaSR is known to regulate some importantcellular processes such as apoptosis and proliferation. CaSR isa drug target for calcimimetics and calcilytics, agents used formodification of parathyroid cells function and treatment of somepathologic conditions. Inactivating or activating mutations ofthe CaSR gene cause different disorders of calcium metabolism.Polymorphic variants of the gene have been described in healthypopulations.

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