Open AccessROL' KAL'TsIY-ChUVSTVITEL'NOGO RETsEPTORA V PODDERZhANII SISTEMY KAL'TsIEVOGO GOMEOSTAZA
Author(s) -
Svetlana Mirnaya,
Ekaterina Pigarova,
A. Belyaeva,
Н. Г. Мокрышева,
A. N. Tyulpakov,
L Ya ROZhINSKAYa
Publication year - 2010
Publication title -
osteoporoz i osteopatii
Language(s) - English
Resource type - Journals
eISSN - 2311-0716
pISSN - 2072-2680
DOI - 10.14341/osteo2010332-36
Subject(s) - calcium sensing receptor , calcium , calcium metabolism , receptor , homeostasis , apoptosis , gene , chemistry , function (biology) , endocrinology , medicine , microbiology and biotechnology , biology , biochemistry
Calcium-sensing receptor (CaSR), a member of G proteincoupledreceptors family, plays a key role in systemic calciumhomeostasis regulation. It is expressed in a variety of tissues, andis responsible for maintaining plasma calcium concentration.In addition, the CaSR is known to regulate some importantcellular processes such as apoptosis and proliferation. CaSR isa drug target for calcimimetics and calcilytics, agents used formodification of parathyroid cells function and treatment of somepathologic conditions. Inactivating or activating mutations ofthe CaSR gene cause different disorders of calcium metabolism.Polymorphic variants of the gene have been described in healthypopulations.