Open AccessEPIDEMIOLOGIChESKIE ASPEKTY PERVIChNOGOGIPERPARATIREOZA V ROSSII
Author(s) -
L Ya ROZhINSKAYa,
Liliya Rostomyan,
Н. Г. Мокрышева,
Svetlana Mirnaya,
Nataliya Kirdyankina
Publication year - 2010
Publication title -
osteoporoz i osteopatii
Language(s) - English
Resource type - Journals
eISSN - 2311-0716
pISSN - 2072-2680
DOI - 10.14341/osteo2010313-18
Subject(s) - medicine , primary hyperparathyroidism , incidence (geometry) , asymptomatic , cinacalcet , retrospective cohort study , endocrine system , hyperparathyroidism , pediatrics , osteoporosis , presentation (obstetrics) , parathyroidectomy , surgery , parathyroid hormone , secondary hyperparathyroidism , hormone , calcium , physics , optics
Primary hyperparathyroidism (PHPT) is the third mostfrequent endocrine disorder and has a variable clinicalpresentation. Asymptomatic PHPT became the predominantform of the disease with increase of its incidence after theintroduction of automated serum calcium measurement inNorth America and Europe. Data from Russia is lacking. Aim:To present the clinical profile of PHPT in Russia. Materialsand Methods: This retrospective study was conducted atendocrinology centers in 8 regions of Russia. We analyzedthe clinical presentation, and treatment options in patientswith confirmed PHPT (1995-2010). Results: 738 patients (F:M-8:1) with age ranging from 13 to 83,4 years (mean 54,3)were analyzed. 54% was from Moscow (n=397), 11% - fromMoscow region (n=79) and 35% - from 53 regions of Russia(n=262). Symptomatic PHPT was the most common form (74%)and was revealed with osteoporosis in 56%, nephrolithiasis - in45% and ulcer disease - in 18%. Our data showed an increasein the incidence of PHPT (especially mild PHPT) after 2005compared with earlier period. 64,9% of patients were treatedsurgically, 17 patients undergone repeated parathyroid surgery.28,3% received bisphosphonates, calcitonin and/or cinacalcet .11,5% was observed without treatment. Conclusions: Thisdata analyzes some causes of delayed diagnosis of PHPT inRussia, characterized age and gender distribution of patientswith PHPT and demonstrates the changes in clinical profile ofdisease from 1995 to 2010. PHPT still remains symptomaticdisorder in our country most frequently with skeletal and renalmanifestations.