Open AccessDINAMIKA MINERAL'NOY PLOTNOSTI KOSTI U RETsIPIENTOV POSLE PERESADKI PEChENI
Author(s) -
И. П. Ермакова,
Ya. G. Moysyuk,
В. П. Бузулина,
Т. К. Колиашвили,
E B Yaroshenko,
М Н Корнилов,
И. А. Пронченко,
Н. П. Шмерко
Publication year - 2009
Publication title -
osteoporoz i osteopatii
Language(s) - English
Resource type - Journals
eISSN - 2311-0716
pISSN - 2072-2680
DOI - 10.14341/osteo200922-4
Subject(s) - medicine , osteopenia , bone mineral , osteoporosis , primary biliary cirrhosis , gastroenterology , cirrhosis , lumbar spine , liver transplantation , immunosuppression , transplantation , surgery
Axial and periferal bone mineral density (BMD) was estimated by DXA twice within 1-47 months in 16 patients following orthotopic liver transplantation (OLT). Osteoporosis and osteopenia of lumbar spine and hip were identified in the first examination of all 9 recipients (group 1) with primary biliary cirrhosis (PBC) and in 5 out of 7 (71%) patients with viral hepatitic cirrhosis (group 2). Recipients which were firstly examined within 1-7 months following OLT (subgroups 1A, 2A) through 9±2.8 months showed in 1A axial BMD elevation (on 20.7+13.2% ; P=0.024) and in 2A axial so as hip BMD elevation (on 10.5+2.7%;P=0.001 and 8.1+5.9%;P< 0.05). Recipients which were examined later 18 months after OLT demonstrated no increase in BMD (subgroups 1B and 2B). Moreover two of them with PBC showed decrease in BMD, probably, as a result of transplant dysfunction and immunosuppression with glucocorticoids.