Open AccessSOSTOYaNIE KOSTNOY TKANI I RISK RAZVITIYa OSTEOPOROZA U ZhENShchIN V STADII POLNOY REMISSIIBOLEZNI ITsENKO-KUShINGA NA FONE FIZIOLOGIChESKOYMENOPAUZY
Author(s) -
L A MARChENKOVA,
А. В. Древаль,
E. Yu. Polyakova,
Р. С. Тишенина,
Н. М. Мылов,
И. П. Ермакова,
И. А. Пронченко,
В. П. Бузулина,
Michele Rubin
Publication year - 2007
Publication title -
osteoporoz i osteopatii
Language(s) - English
Resource type - Journals
eISSN - 2311-0716
pISSN - 2072-2680
DOI - 10.14341/osteo2007313-20
Subject(s) - medicine , osteoporosis , bone remodeling , lumbar spine , hormone , postmenopausal women , gynecology , gastroenterology , urology , surgery
It is well known that clinical signs of endogenous hypercorticism including secondary osteoporosis rapidly reverse on the base of hormonal remission after radiosurgical treatment of Cushing's disease (CD). The aim of the study was to assess BMD and bone turnover biochemical markers in postmenopausal women with complete CD-remission.We examined 43 women aged 38-67 years in physiological postmenopause who had a complete long-term hormonal CD-remission for at least 2 years (11±6,8 years in average) after combine treatment with hemiadrenalectomy and radiosurgery. Control group comprised 98 healthy postmenopausal women at the same age and postmenopausal age.Our main findings were BMD in postmenopausal CD-patients was higher vs. controls in lumbar spine (1,233±0,17 vs. 1,146±0,20 g/cm2, p