Open AccessEFFEKTIVNOST', PERENOSIMOST'I KOMPLAENTNOST' ALENDRONATA NATRIYa(70 MG 1 RAZ V NEDELYu)PRI LEChENII POSTMENOPAUZAL'NOGO OSTEOPOROZA
Author(s) -
А. В. Древаль,
L A MARChENKOVA,
I. V. Kryukova,
Р. С. Тишенина,
Lewis M. Portnoy,
Н. М. Мылов,
Michele Rubin
Publication year - 2006
Publication title -
osteoporoz i osteopatii
Language(s) - English
Resource type - Journals
eISSN - 2311-0716
pISSN - 2072-2680
DOI - 10.14341/osteo2006213-17
Subject(s) - medicine , osteoporosis , tolerability , femoral neck , trochanter , calcium , postmenopausal women , lumbar spine , surgery , adverse effect
The aim of this study was to assess effectiveness ant tolerability of alendronate in women suffered of postmenopausal osteoporosis.15 postmenopausal women with primary osteoporosis (age 61.0±4.8 (M±σ) years) was administered alendronate in dosage 70 mg weekly with calcium supplementation (1000 mg daily) for 12 months. Control group consisted of 19 women also suffered from postmenopausal osteoporosis (age 61.7±5.2 years) received only calcium salts for study period.There was a significant increase vs baseline in BMD in lumbar spine (in 2.1% in 6 months and in 2.7% in 12 months), in femoral neck from (in 2.1% and 3.3% accordingly), in trochanter (in 5.5% and 6.3% accordingly) and in total proximal femur (in 2.9% and 1.9% accordingly) in treated patients. We also found in treated group a marked decrease in serum ionized calcium from 1.24±0.03 to 1.21±0.03 mmol/l in 6 months and to 1.2±0.04 mmol/l in 12 months (р