Open AccessIZMENENIYa KOSTNOY TKANI ChELOVEKAV KOSMIChESKOM POLETE: O VOZMOZhNYKh MEKhANIZMAKh OSTEOPENII
Author(s) -
В. С. Оганов,
А. В. Бакулин,
V. V. Novikov,
Л. М. Мурашко,
O. E. Kabitskaya
Publication year - 2005
Publication title -
osteoporoz i osteopatii
Language(s) - English
Resource type - Journals
eISSN - 2311-0716
pISSN - 2072-2680
DOI - 10.14341/osteo200522-7
Subject(s) - bone resorption , endocrinology , reabsorption , medicine , osteolysis , homeostasis , bone remodeling , calcium , calcium metabolism , chemistry , resorption , kidney , dentistry
Some results of possible participation of bone metabolism regulation different levels in the bone changes caused by microgravity are presented taking into account the body fluid redistribution which usually accompany the space flight. The primary starting changes associate with biomechanical factors and realize on the strictly bone level (osteocytic osteolysis, breach of «collagen-crystal» connection, slowing of osteoblastic histogenesis). There are calcium homeostasis distortion on the extrabone (tissue, organs) level: decrease of calcium intestinal absorption and renal reabsorption. Changes in the hierarchy of ion and fluid volume regulation systems may provoke the osteoclastic resorption, which intensify the bone loss.