Open AccessAssociations of sex hormones with components of insulin-glucose homeostasis
Author(s) -
О. В. Цыганкова,
Artur R Badin,
Zoya G Bondareva,
Н. Г. Ложкина,
D. Yu. Platonov
Publication year - 2018
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/omet201823-10
Subject(s) - hormone , glucose homeostasis , adipokine , insulin , leptin , endocrinology , medicine , insulin resistance , adiponectin , homeostasis , biology , obesity
In this literature review, an attempt is made to analyze the interrelationships of the main sex hormones with the processes of development and progression of insulin resistance as a fundamental pathogenetic component of insulin-glucose homeostasis. In the evaluation of sex steroids, a complex approach was used - the associations of both androgens and estrogens in males and females are described in detail, a great deal of attention is paid to the violation of the secretion and effectiveness of the main adipocytokines - leptin and adiponectin in the sex hormone-insulin-glucose interaction chain. At the end of the review, new data on the expression of sodium-dependent glucose cotransporter (SGLT) and glucose transporters (GLUT) in animals, depending on sex, are presented.