Open AccessMetabolic changes in patients with familial pituitary adenomas associated with mutations in the AIP gene
Author(s) -
Т. С. Тарасова,
Ekaterina Pigarova,
Larisa Dzeranova,
Anatoly Tiulpakov,
Ivan I. Dedov
Publication year - 2017
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/omet2017148-51
Subject(s) - gene , gene mutation , medicine , mutation , bioinformatics , pituitary tumors , genetics , biology
Currently, many AIP mutations responsible for the development of pituitary adenomas have been described. Penetence of pituitary adenomas in AIP-positive FIPA families is incomplete and varies widely. Data on the characteristics of metabolic changes in patients with familial pituitary adenomas associated with mutations in the AIP gene continues to be inadequate. Evaluation of the results of molecular genetic studies, as well as a thorough analysis of metabolic changes in these clinical cases, will help to develop and improve diagnostic and treatment algorithms, identify patient groups that require special attention of endocrinologists, timely screening, aggressive treatment, and careful dynamic observation.