Open AccessDrugs for the treatment of central diabetes insipidus: historical background and modern opportunities
Author(s) -
Darya Mikhaylova,
Ekaterina Pigarova,
Larisa Dzeranova
Publication year - 2017
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/omet2017117-23
Subject(s) - polyuria , diabetes insipidus , polydipsia , desmopressin , vasopressin , medicine , endocrinology , nasal administration , pediatrics , pharmacology , diabetes mellitus
Central diabetes insipidus is a severe disease with disturbance of arginine vasopressin secretion, which leads to excretion of large amounts of hypotonic urine. The polyuria-polydipsia syndrome is essential as a clinical presentation and high impact condition. Desmopressin, a synthetic analog of arginine vasopressin, is used to compensate a water-electrolyte balance is available in forms of tablets and intranasal spray. Free drug choice is obligated for proper treatment.