Silent pituitary adenomas: review and clinical cases | Zendy

A K Lipatenkova | Zendy; Липатенкова Анна Константиновна | Zendy; Larisa Dzeranova | Zendy; Дзеранова Лариса Константиновна | Zendy; Ekaterina Pigarova | Zendy; Пигарова Екатерина Александровна | Zendy; Ludmila Igorevna Astaf'eva | Zendy; Астафьева Людмила Игоревна | Zendy; Andrey Yur'evich Grigor'ev | Zendy; Григорьев Андрей Юрьевич | Zendy; Ludmila Valentinovna Shishkina | Zendy; Шишкина Людмила Валентиновна | Zendy; Vladislav Yur'evich Cherebilo | Zendy; Черебило Владислав Юрьевич | Zendy; Anastasiya Pavlovna Ektova | Zendy; Эктова Анастасия Павловна | Zendy

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Silent pituitary adenomas: review and clinical cases

Author(s) -

A K Lipatenkova,

Липатенкова Анна Константиновна,

Larisa Dzeranova,

Дзеранова Лариса Константиновна,

Ekaterina Pigarova,

Пигарова Екатерина Александровна,

Ludmila Igorevna Astaf'eva,

Астафьева Людмила Игоревна,

Andrey Yur'evich Grigor'ev,

Григорьев Андрей Юрьевич,

Ludmila Valentinovna Shishkina,

Шишкина Людмила Валентиновна,

Vladislav Yur'evich Cherebilo,

Черебило Владислав Юрьевич,

Anastasiya Pavlovna Ektova,

Эктова Анастасия Павловна

Publication year - 2015

Publication title -

obesity and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.154

H-Index - 5

eISSN - 2306-5524

pISSN - 2071-8713

DOI - 10.14341/omet2015239-46

Subject(s) - immunohistochemistry , hormone , pituitary hormones , medicine , pituitary adenoma , adenoma , pituitary gland , pathology , endocrinology , biology

Silent, or clinically nonfunctioning adenomas are morphologically heterogeneous group, characterized by positive immunoreactivity for one or more hormones classically secreted by normal pituitary cells but without clinical expression. Although in some occasions enhanced or changed secretory activity can develop over time. According to immunoreactivity they are divided into "silent" gonado-, cortico-, somato -, mammo – and thyrotropinomas, oncocytomas, «zero-cell» tumors. All types of "silent" adenomas have different biological activity, secretory capacity and outcomes in the postoperative period. This series of clinical cases shows more «aggressiveness», a higher risk of relapse for "silent" cortico- and somatotropinomas. Immunohistochemical analysis of residual tissue can be used to identify patients with high risk of recurrence, to develop optimal treatment and follow-up.

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