Open AccessSilent pituitary adenomas: review and clinical cases
Author(s) -
A K Lipatenkova,
Липатенкова Анна Константиновна,
Larisa Dzeranova,
Дзеранова Лариса Константиновна,
Ekaterina Pigarova,
Пигарова Екатерина Александровна,
Л. И. Астафьева,
Астафьева Людмила Игоревна,
Andrey Grigorev,
Григорьев Андрей Юрьевич,
Л. В. Шишкина,
Шишкина Людмила Валентиновна,
Vladislav Yur'evich Cherebilo,
Черебило Владислав Юрьевич,
Anastasia Shekhtman,
Эктова Анастасия Павловна
Publication year - 2015
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/omet2015239-46
Subject(s) - immunohistochemistry , hormone , pituitary hormones , medicine , pituitary adenoma , adenoma , pituitary gland , pathology , endocrinology , biology
Silent, or clinically nonfunctioning adenomas are morphologically heterogeneous group, characterized by positive immunoreactivity for one or more hormones classically secreted by normal pituitary cells but without clinical expression. Although in some occasions enhanced or changed secretory activity can develop over time. According to immunoreactivity they are divided into "silent" gonado-, cortico-, somato -, mammo – and thyrotropinomas, oncocytomas, «zero-cell» tumors. All types of "silent" adenomas have different biological activity, secretory capacity and outcomes in the postoperative period. This series of clinical cases shows more «aggressiveness», a higher risk of relapse for "silent" cortico- and somatotropinomas. Immunohistochemical analysis of residual tissue can be used to identify patients with high risk of recurrence, to develop optimal treatment and follow-up.