Open AccessThe role of insulin, leptin, adiponectin in forming of structural and functional changes of myocardium in obesity and their dynamics in weight loss.
Author(s) -
А. В. Постоева,
Irina Vladimirovna Dvoryashinva
Publication year - 2015
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/omet2015210-13
Subject(s) - adiponectin , hyperinsulinemia , leptin , medicine , insulin resistance , endocrinology , insulin , obesity , weight loss , subclinical infection , metabolic syndrome
The aim of this work was a review of literature data on the possible relationships between the levels of insulin, leptin, and adiponectinand the formation of structural and functional changes in the myocardium in obesity, as well as their dynamics due to body weight reduction.We analyzed the studies found by keywords «insulin, adiponectin, leptin, left ventricular hypertrophy» in international databasesPubmed, Medline and Cochrane. Results of many studies suggest a positive association with hyperinsulinemia and hyperleptinemia massindex and left ventricular mass. Insulin resistance can act as an independent predictor of subclinical diastolic dysfunction. Contributionof adiponectin in the development of cardiovascular diseases has been investigated extensively: many authors have obtained results thatindicate its protective effect on the myocardium. Weight reduction is associated with decrease in levels of blood insulin and leptin, butleptin reduction, according to some authors, there was only seen in a decrease in body weight by an amount exceeding 7% of the original.The results of measuring the level of adiponectin in obese patients on the background of weight loss remains controversial: some authorshave obtained an increase in the concentration of this protein in the blood, while others pointed out the lack of any dynamics.