Open AccessMetformin represses drug – induced expression of CYP2B6 by the constitutive androstane receptor phosphorylation
Author(s) -
Andreeva Sveta Igorevna
Publication year - 2014
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/omet2014360-61
Subject(s) - metformin , constitutive androstane receptor , gluconeogenesis , drug , type 2 diabetes , medicine , pharmacology , endocrinology , glycolysis , diabetes mellitus , chemistry , nuclear receptor , metabolism , biochemistry , gene , transcription factor
Currently, metformin is a major hypoglycemic agents for the treatment of type 2 diabetes. The main antihyperglycemic effect of metformin - suppression of hepatic gluconeogenesis and glycolysis. However, type 2 diabetes are usually associated with other diseases and associated comorbid conditions that require polifarmakologic treatment.