Metformin represses drug – induced expression of CYP2B6 by the constitutive androstane receptor phosphorylation | Zendy

Sveta Igorevna Andreeva | Zendy

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Metformin represses drug – induced expression of CYP2B6 by the constitutive androstane receptor phosphorylation

Author(s) -

Sveta Igorevna Andreeva

Publication year - 2014

Publication title -

obesity and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.154

H-Index - 5

eISSN - 2306-5524

pISSN - 2071-8713

DOI - 10.14341/omet2014360-61

Subject(s) - metformin , constitutive androstane receptor , gluconeogenesis , drug , type 2 diabetes , medicine , pharmacology , endocrinology , glycolysis , diabetes mellitus , chemistry , nuclear receptor , metabolism , biochemistry , gene , transcription factor

Currently, metformin is a major hypoglycemic agents for the treatment of type 2 diabetes. The main antihyperglycemic effect of metformin - suppression of hepatic gluconeogenesis and glycolysis. However, type 2 diabetes are usually associated with other diseases and associated comorbid conditions that require polifarmakologic treatment.

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