Open AccessMetformin and male reproduction: effects on Sertoli cell metabolism
Author(s) -
Teona Albertovna Shvangiradze
Publication year - 2014
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 5
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/omet2014357-58
Subject(s) - metformin , polycystic ovary , sertoli cell , infertility , endocrinology , medicine , biology , type 2 diabetes , in vivo , diabetes mellitus , gynecology , insulin resistance , pregnancy , spermatogenesis , genetics
Metformin, widely used for the treatment of type 2 diabetes, is increasingly becoming the subject of research in other areas of medicine. Apart form antihyperglycemic effect of metformin has an inhibitory effect on the proliferation of various tumor cells both in vivo and in vitro. Metformin is well established in the treatment of anovulatory infertility in polycystic ovary syndrome, while its influence male reproductive function are poorly understood.