Open AccessHigh prevalence of low vitamin D levels in endocrine disorders
Author(s) -
Ekaterina Pigarova,
Larisa Dzeranova
Publication year - 2022
Publication title -
ožirenie i metabolizm
Language(s) - English
Resource type - Journals
eISSN - 2306-5524
pISSN - 2071-8713
DOI - 10.14341/omet12799
Subject(s) - acromegaly , medicine , endocrine system , endocrine disease , vitamin d deficiency , diabetes mellitus , vitamin d and neurology , type 2 diabetes mellitus , inclusion and exclusion criteria , gastroenterology , hyperparathyroidism , endocrinology , vitamin , primary hyperparathyroidism , hormone , pathology , growth hormone , alternative medicine
BACKGROUND: Vitamin D deficiency and insufficiency are widespread medical abnormalities, but their frequency in endocrine diseases has generally not been studied. AIM: To provide a comparative assessment of vitamin D levels in patients with diabetes mellitus type 2, primary hyperparathyroidism (PHPT), central hypercortisolism (Cushing’s disease; CD) and acromegaly. MATERIALS AND METHODS: Total 25(OH)D was determined using the immunochemiluminescent method (the laboratory participates in the DEQAS program). All patients had GFR > 60 ml/min, no history of use of vitamin D supplementation within previous month. RESULTS: The study included 365 patients who, after applying the inclusion/exclusion criteria, were divided into 5 main research groups: 33 patients with diabetes mellitus type 2, 23 patients with PHPT, 68 patients with CD, 22 patients with acromegaly, and 141 apparently healthy patients. Significantly low levels of vitamin D were found in patients with diabetes mellitus type 2 (14.8 ng/ml), acromegaly (14.9 ng/ml), CD (14.6 ng/ml), and PHPT (15.9 ng/ml) compared with a group of otherwise healthy patients (18.8 ng/ml). CONCLUSION: The results of the study demonstrate a high prevalence of vitamin D deficiency not only in groups of patients with chronic diseases, but also among practically healthy patients. Further studies are needed to address the causes of high vitamin D deficiency in the described endocrine diseases.