Open AccessImmunity-mediated diseases and human immunogenetics (accomplishments and prospects)
Author(s) -
Ivan I. Dedov,
Р. М. Хаитов,
L. Alexeev
Publication year - 2016
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/dm7775
Subject(s) - immunogenetics , human leukocyte antigen , immunity , type 1 diabetes , haplotype , immunology , disease , genotype , medicine , biology , diabetes mellitus , genetics , immune system , antigen , gene , endocrinology
Type 1 diabetes mellitus (T1DM) was used from the viewpoint of human immunogenetics as an example of the most widely studied immunity-mediated disease. This was done in order to develop, approve and implement a new clinical approach to determine immunity-mediated susceptibility or resistance to autoimmune diseases. The approach is based on analysis of entire HLA-DRB1 genotypes (not separate HLA-DRB1 haplotypes) of the study participants. Therefore, more effective and personalised classification of T1DM risk groups was achieved by exclusion from significant contingents.