In search of the Somogyi effect

The Somogyi phenomenon or rebound hyperglycaemia is known as the counterregulatory response to asymptomatic nocturnal hypoglycaemia; the Somogyi phenomenon occurs with high fasting blood glucose levels and hyperglycaemia the following morning. Most published trials, however, do not agree with this theory. Although data from some experimental studies may suggest a pathophysiological link. Perhaps, the differences in research results are caused by the evolution of blood glucose monitoring methods. Nevertheless, it cannot be excluded that the results of Michael Somogyi’s studies were misunderstood.