The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome | Zendy

Ekaterina L. Zaitseva | Zendy; Ludmila Petrovna Doronina | Zendy; R V Molchkov | Zendy; Iya А. Voronkova | Zendy; Alla Yur'evna Tokmakova | Zendy

Open Access

The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome

Author(s) -

Ekaterina L. Zaitseva,

Ludmila Petrovna Doronina,

R V Molchkov,

Iya А. Voronkova,

Alla Yur'evna Tokmakova

Publication year - 2015

Publication title -

diabetes mellitus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.155

H-Index - 12

eISSN - 2072-0378

pISSN - 2072-0351

DOI - 10.14341/dm7587

Subject(s) - cd68 , granulation tissue , immunohistochemistry , medicine , osteopontin , pathology , cd31 , diabetes mellitus , extracellular matrix , diabetic foot , infiltration (hvac) , staining , wound healing , surgery , biology , endocrinology , physics , microbiology and biotechnology , thermodynamics

Aim. To evaluate the morphological and immunohistochemical features of granulation tissue formation in patients with diabetic foot syndrome.Materials and methods. We analysed the histological (light microscopy) and immunohistochemical (CD31, CD68, osteopontin, MMP-9 and TIMP-1) features of tissue repair processes in patients with diabetes mellitus. The study involved 63 patients with diabetic foot syndrome after surgical debridement.Results. We found severe intercellular oedema, poorly organised extracellular matrix, small amounts of fibroblast-like cells and expressed inflammatory infiltration, along with the presence of young granulation tissue. According to the results of the immunohistochemical studies, there were a moderate number of macrophages (immunopositive with antibodies to CD68), intense staining of MMP-9 and weak staining of TIMP-1 and osteopontin.Conclusion. According to the findings of the histological and immunohistochemical studies, tissue repair processes in patients with diabetes mellitus are decelerated.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research