Open AccessRelationship of hypoglycemia and glucose variability with autonomic dysfunction in children and adolescents with type 1 diabetes
Author(s) -
Д. Н. Лаптев,
Лаптев Дмитрий Никитич
Publication year - 2014
Publication title -
saharnyj diabet
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 12
eISSN - 2072-0378
pISSN - 2072-0351
DOI - 10.14341/dm2014487-92
Subject(s) - medicine , heart rate variability , hypoglycemia , type 1 diabetes , autonomic neuropathy , diabetes mellitus , continuous glucose monitoring , cardiology , qt interval , autonomic nervous system , heart rate , endocrinology , blood pressure , biology , cell culture , genetics , neuroblastoma
Aim. Glucose variability (GV) and hypoglycaemia frequency and duration, depending on cardiovascular autonomic dysfunction, in children and adolescents with type 1 diabetes mellitus (T1DM) were evaluated. Materials and methods. One hundred and thirty T1DM patients, aged 6?18 years, were included in this study. The study included 3 tests:. continuous glucose monitoring (CGM) with GV evaluation, frequency and duration of hypoglycaemia;24-h ECG monitoring with automatic calculation of QTc interval and heart rate variability (HRV) parameters;cardiovascular autonomic tests.Results. The estimated prevalence of cardiovascular autonomic neuropathy (CAN) was 19.2%. CAN positive (CAN+) patients had lower values from cardiovascular autonomic tests and HRV and longer QTc intervals compared with CAN negative (CAN-) patients (p